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Sex and Uprima

Sex and Uprima
by David Jay Brown 

Uprima (Apomorphine Hydrochloride) is a prescription drug that enhances a man’s ability to achieve and maintain an erection about as reliably as Viagra, yet most men in America don’t know about it because it’s used primarily in Europe.

Uprima is a chemical relative of morphine, although it has no morphine-like effects, and is, in fact, a stimulant. It was developed as a treatment for Parkinson’s Disease, but, early on, it became clear that it might have other uses after many of the Parkinson’s patients began getting erections when they received the drug. Marketed in Europe under the trade name Uprima, it is now widely prescribed by physicians in Europe as an effective treatment for male erectile dysfunction (ED) or impotence.

Uprima was the first oral therapy to be approved by the European Commission for the treatment of ED, and although Uprima has not yet been approved for sale in the United States, U.S. residents are legally allowed to order a (up to 3 month) personal supply of the drug from European pharmacies because it is not a controlled substance, and it meets the FDA Medication Import Policy guidelines.

Uprima is a type of drug known as a dopamine receptor agonist, and it works differently than Viagra does to facilitate erections. (Dopamine is an excitatory neurotransmitter, a chemical that causes excitement in the brain.) Viagra works by enhancing the effect of a chemical in the body called Nitric Oxide, which effects the vascular system, and temporarily widens arteries, thus increasing blood flow to the penis.

Uprima acts through the dopamine receptors in the mid-brain, and a part of the brain called the hypothalamus, which is the region responsible for initiating erections. When Uprima stimulates the hypothalamus, it inhibits the body’s smooth muscle contractions, and this allows for more blood to enter the penis, so erections occur easier and more frequently.

However, like Viagra, Uprima will only work to facilitate erections when sexual stimulation is present. It does not increase sex drive and it is not an aphrodisiac.

In recent studies, Uprima produced erections in men with erectial dysfunction about as reliably as Viagra (between 70 and 90 percent of the time), and it has been clinically shown to help men achieve an erection two to three times faster than Viagra. Uprima starts acting within 15 to 30 minutes (around 20 minutes on average), while Viagra usually takes between 30 minutes and an hour.

This is because Uprima tablets are taken sublingually-that is, they dissolve under the tongue. Viagra, on the other hand, is swallowed as a pill, which takes longer to enter the blood stream. Because of the sublingual mode of delivery, one of the benefits to using Uprima over Viagra-besides the fact that it works faster-is that you can take it after eating, without lessening the effects of the drug.

Like Viagra, Uprima shouldn’t be used by people with hypertension or heart problems. In clinical trials, the most commonly reported adverse reactions to Uprima were nausea, headache and dizziness, which were said to be generally mild and transient in nature.

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